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Category:14th-century deaths Category:Architects from London Category:14th-century English people Category:Medieval English architects Category:Year of birth unknown3-haloalkylthio-1-pyridinium salts (V) as new inhibitors of the mammalian target of rapamycin. The inhibition of the mammalian target of rapamycin (mTOR) by 3-haloalkylthio-1-pyridinium salts is described. The ATP competitive inhibition is characterized by Ki values in the nanomolar range. The halide atom at the pyridinium ring is essential for the inhibition of mTOR, while the nature of the alkylthio group is critical for the inhibition. 3-Iodo-1-pyridinium salts, 3-iodo-1-piperidinium salts, and 3-iodo-1-pyrrolidinium salts are only weak inhibitors, and the inhibition is probably not an ATP-competitive inhibition.Q: Is $A/I$ the Jacobson radical of $A$? Let $A$ be a ring and let $I$ be an ideal of $A$. Is $A/I$ the Jacobson radical of $A$? A: Yes, if $A$ is commutative and $I$ is an ideal with $ ext{rad}(I)=0$, then $A/I$ is Jacobson radical by Artin's theorem and proposition 11 of this book. If $A$ is commutative, then the Jacobson radical $J(A)$ of $A$ is $A$ itself, by the preceding question. Now the Jacobson radical $J(A/I)$ of $A/I$ is $J(A)/I$, since $J(A/I) = J(A)/I$. Now $I = J(A)/I$, so $A/I = J(A)/I$, and $J(A/I)$ is equal to $J(A)/I$. This means $J(A/I) = J(A)/I = J(A)$, and the Jacobson radical of $A/I$ is the Jacobson radical of $A$. Q: get video file

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